A high prevalence of tylosin resistance among Staphylococcus aureus strains isolated from bovine mastitis
نویسندگان
چکیده
The macrolides appear to have considerable effects for treatment of bovine mastitis because of excellent diffusion into the mammary gland, long half-life, low protein binding, high intracellular concentration and lipid solubility. Acquired resistance to macrolides in Staphylococcus aureus is primarily related to target-site modification through acquisition of an erm gene. In the present study the prevalence of both phenotypic and genotypic tylosin resistance in S. aureus isolates (n = 103) from subclinical mastitis in nine dairy farms belonging to three different province of Iran were investigated. Overall, ermA, ermB and ermC was found in 7.80%, 32.00%, and 20.40% of S.aureus isolates, respectively. A very high percent of isolates (56.90%) were resistant to tylosin. MIC90 and MIC50 values were 64 and 32 µg mL-1, respectively. Most of tylosin resistant isolates did not harbour any erm gene but ermB was dominant gene among 58 tylosin resistant isolates of S. aureus. In overall, tylosin resistance was prevalent in S. aureus isolates obtained from bovine mastitis in Iran.
منابع مشابه
A high prevalence of tylosin resistance among Staphylococcus aureus strains isolated from bovine mastitis
The macrolides appear to have considerable effects for treatment of bovine mastitis because of excellent diffusion into the mammary gland, long half-life, low protein binding, high intracellular concentration and lipid solubility. Acquired resistance to macrolides in Staphylococcus aureus is primarily related to target-site modification through acquisition of an erm gene. In t...
متن کاملFrequency of specific agr groups and antibiotic resistance in Staphylococcus aureus isolated from bovine mastitis in the northeast of Iran
Staphylococcus aureus is generally regarded as a leading cause of mastitis in dairy cattle. The aim of this study was to investigate the pattern of agr groups and any possible relationship between agr groups and antibiotic resistance among S. aureus strains isolated from bovine mastitis in Northeast of Iran. For this purpose, a total of 300 bovine mastitic mi...
متن کاملAntibiotic Susceptibility and Plasmid Profiles of Staphylococcus aureus Strains Isolated from Bovine Subclinical Mastitis in Tabriz, Iran
ABSTRACT Background and Objectives: Mastitis caused by Staphylococcus aureus is a widely distributed disease in cattle, goats and sheep. The infection is often subclinical in cattle, leading to reduced milk production and quality, but acute catarrhal or even gangrenous inflammation may also occur. The aim of this study was to investigate resistance of S. au...
متن کاملHigh Frequency of biofilm related genes (icaD, fnbA, icaA and clfA) among Staphylococcus aureus isolated from bovine with subclinical mastitis
Background and aim: Regarding to the importance of Staphylococcus aureuscolonization in bovine mastitis and the role of biofilm in its pathogenesis, the aim of the present study were to assessment of biofilm production and identification of biofilm related genes among S. aureus isolated from bovine with subclinical mastitis. Materials and Methods: In this cross-sectional study, a total of 502 m...
متن کاملCharacterization of Staphylococcus aureus strains involved in human and bovine mastitis.
Staphylococcus aureus is one of the main etiological agents of mastitis in different mammalian species. At present, it is unknown whether strains isolated from human mastitis cases share phenotypic properties and genetic background with those obtained from animal mastitis cases. Therefore, the objective of this study was to characterize S. aureus strains isolated from women with lactational mas...
متن کامل